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DERINAT - IMMUNOMODULATING AGENT

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Products:

DERINAT solution for external and local application, 10 ml – spray

DERINAT solution for external and local application, 10 ml - bottle-dropper

DERINAT solution for external and local application, 10 ml – bottle

DERINAT solution for intramuscular injection of 15 mg / ml, in vials of 5 ml, №5

Prevention of acute viral infectious diseases in the elderly and people with weakened immune systems is a difficult task, since such people often respond poorly to active immunization methods.  Pharmacologically induced immune responses to respiratory viral infections should enhance the natural defense mechanisms of the mucosal epithelium of the upper respiratory tract. One of these mechanisms is the synthesis of immunoglobulin A (IgA) by epithelial cells.

Immunoglobulins A are glycoproteins that are synthesized by the epithelium and plasma cells of the mucous membranes in response to local exposure to the antigen of the virus. In the human body, IgA exists in two forms - serum and secretory (sIgA). Their T1 \ 2 is 6-7 days.

Secretory immunoglobulin A (sIgA) is found in the secretion of the mucous membranes of the upper respiratory tract and bronchi, and is an important factor in their local protection. Antibodies (sIgA) non-specifically bind (opsonize) the antigens of microorganisms that have fallen on the surface of the mucous membrane, stimulating special cells of the immune system (macrophages, leukocytes) to destroy them, enhancing phagocytosis of antigens by activating complement along an alternative pathway.

It is known that an increase in the synthesis of sIgA by epithelial cells and plasma cells of the mucous membrane of the upper respiratory tract and bronchi occurs, among other things, when their innate immune response to pattern recognition receptors (PAMP) is stimulated. PAMPs are proteins present on the surface of cells of the immune system and capable of recognizing standard molecular structures (patterns) specific to large groups of pathogens (viruses, bacteria, fungi, etc.).

These receptors of the innate immune response include Toll-like receptors (English Toll-like receptor, TLR; from German toll - wonderful) - a class of cellular receptors with one transmembrane fragment that recognizes conservative parts of the structures of bacteria and viruses that cannot be they are changed in the process of evolution and activate the body's immune response. To date, 10 types of Toll-like receptors (TLR1, TLR2...TLR9) have been identified in humans.

DERINAT® is an immunomodulator that selectively stimulates Toll-like receptors 9 (TLR9). TLR9 are located on macrophages, dendritic cells of any localization, B-lymphocytes. The study of the nucleotide composition of the terminal sections of the DNA fragments that are part of the preparation "Derinat"® showed that the fragments end in an unmethylated CpG dinucleotide motif. Unmethylated CpG DNA motifs are specific ligands for TLR9.

Studies conducted by our company have shown that the local application of the drug "Derinat"®, in the form of a 0.25% solution, significantly increases the synthesis of secretory immunoglobulin A (sIgA) on the surface of the mucous membrane of the upper respiratory tract.

Thus, in the context of the COVID-19 pandemic, in the absence of a vaccine, our company offers an alternative preventive strategy for controlling the incidence by pharmacological induction of the innate immune response by enhancing the synthesis of secretory immunoglobulin A (sIgA) by epithelial cells of the mucous membrane of the upper respiratory tract and bronchi.

 

DERINAT - Immunomodulating Agent

DERINAT 0.25% (immunomodulating agent in solution spray bottle)

Derinat is a reliable remedy for...

29,00 €
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DERINAT 0.25% (immunomodulating agent in solution bottle-dropper)

Derinat is a reliable remedy for...

26,00 €
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DERINAT 0.25% (immunomodulating agent in solution bottle)

Derinat is a reliable remedy for...

26,00 €
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DERINAT (solution for intramuscular injection 15 mg / ml, in vials of 5 ml, No. 5)

Derinat is a reliable remedy for...

69,00 €
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